RE: restart NONMEM
Yes, restarting NONMEM using the MSF system for a multi $EST methods problem is
sufficiently complex, that it is best to leave it to the user to decide what
needs to be done (that is, modifying the control stream file for the
appropriate re-start action), rather than trying to make an intelligent
algorithm within NONMEM that won't get tripped up. For example, in the case
where a problem is interrupted with several $EST statements, the user needs to
modify the control stream file by inserting the $MSFI statement. While there,
it is possible for the user to change the series or order, or even the options
of the $EST statements as well. As for the MSF file, even if it stored which
$EST statement it was on when interruption occurred, this was in accordance
with the original control stream file, and not in accordance with the present
control stream file. It is best to simply have the user note during which step
it crashed, and manually comment out the $EST steps that were already executed.
Furthermore, it may be desirable for the user to modify the options of the
$EST record that is being repeated, for example, to change the number of NBURN
iterations in an SAEM step, etc.
Robert J. Bauer, Ph.D.
Vice President, Pharmacometrics, R&D
ICON Development Solutions
7740 Milestone Parkway
Suite 150
Hanover, MD 21076
Tel: (215) 616-6428
Mob: (925) 286-0769
Email: [email protected]
Web: www.iconplc.com
Quoted reply history
-----Original Message-----
From: [email protected] [mailto:[email protected]] On
Behalf Of Nick Holford
Sent: Wednesday, August 15, 2012 3:20 PM
To: nmusers
Subject: Re: [NMusers] restart NONMEM
Bob,
The complexity of restarting NM7.2 when multiple $EST are used is really
something that needs to be addressed within NONMEM.
Its not something I will be attempting with WFN.
Best wishes,
Nick
On 15/08/2012 11:46 p.m., Hiker Hiker wrote:
> Hi Nick,
> WFN provides a great support.
> NONMEM7.2 is complex. INTER file is empty sometimes. The restart
> commants may need some additional options when several methods are
> used in the same *.CTL file.
> Cheers,
> Bob
>
> *From:* Nick Holford <[email protected]>
> *To:* nmusers <[email protected]>
> *Sent:* Tuesday, August 14, 2012 3:19 PM
> *Subject:* Re: [NMusers] restart NONMEM
>
> Bob,
>
> First of all you need to restart your spell checker -- this is the
> NONMEM user group :-)
>
> WFN can help restart if you include the MSFO option in the $EST record.
> The nmctl command with the 'i' option will copy the intermediate
> output parameter estimates (using the INTER file) from the last
> iteration into the NM-TRAN control stream. You can then restart the run.
>
> Nick
>
>
>
> On 14/08/2012 11:28 p.m., Hiker Hiker wrote:
> >
> > Dear NONMEN Users:
> > What are the most efficient ways to restart NONMEM if it is
> > interrupted? NONMEM allows only one MSFO statement when several
> > methods are used.
> > Can supporting software packages such as PsN, xpose, wings of
> > NONMEM, etc. help?
> > Cheers,
> > Bob
> >
>
> -- Nick Holford, Professor Clinical Pharmacology
>
> First World Conference on Pharmacometrics, 5-7 September 2012
> Seoul, Korea http://www.go-wcop.org
>
> Dept Pharmacology & Clinical Pharmacology, Bldg 505 Room 202D
> University of Auckland,85 Park Rd,Private Bag 92019,Auckland,New Zealand
> tel:+64(9)923-6730 fax:+64(9)373-7090 mobile:+64(21)46 23 53
> email: [email protected] <mailto:[email protected]>
> http://www.fmhs.auckland.ac.nz/sms/pharmacology/holford
>
>
>
>
--
Nick Holford, Professor Clinical Pharmacology
First World Conference on Pharmacometrics, 5-7 September 2012
Seoul, Korea http://www.go-wcop.org
Dept Pharmacology & Clinical Pharmacology, Bldg 505 Room 202D
University of Auckland,85 Park Rd,Private Bag 92019,Auckland,New Zealand
tel:+64(9)923-6730 fax:+64(9)373-7090 mobile:+64(21)46 23 53
email: [email protected]
http://www.fmhs.auckland.ac.nz/sms/pharmacology/holford