RE: error message 0VAR-COV OF SOME OBS ESTIMATED TO BE 0 - a bug?
Pavel:
If you do not mind sharing your control stream file, and if necessary,
your data file (or a truncated version of it), perhaps you could send it
to me. I may be able to determine if there is a way to modify the
control stream code to avoid these errors, or if there is a bug.
Robert J. Bauer, Ph.D.
Vice President, Pharmacometrics
ICON Development Solutions
Tel: (215) 616-6428
Mob: (925) 286-0769
Email: [email protected]
Web: www.icondevsolutions.com
Quoted reply history
________________________________
From: [email protected] [mailto:[email protected]]
On Behalf Of [email protected]
Sent: Thursday, February 03, 2011 9:32 AM
To: Martin Johnson
Cc: [email protected]
Subject: Re: [NMusers] error message 0VAR-COV OF SOME OBS ESTIMATED TO
BE 0 - a bug?
Thank you Martin,
It was helpful and educational, but did not resolve the issue. I just
used a very different code and datasets. The only common part was
$EST MAXEVALS=9999 SIG=5 NOABORT PRINT=1 SORT
METHOD=IMP CTYPE=3 NITER=1000 ISAMPLE=300 POSTHOC INTERACTION
There are no warnings or errors. Newertheless, the code creates 2 out
of 4 requested output files. Both output files are truncated, i.e.
after a certain subject and a timepoint there are no output records. It
does not depend on the number of added dummy time points (MDV=1). What
can it be?
Thanks,
Pavel
----- Original Message -----
From: Martin Johnson
Date: Friday, January 28, 2011 1:52 am
Subject: Re: [NMusers] error message 0VAR-COV OF SOME OBS ESTIMATED TO
BE 0 - a bug?
To: [email protected]
> Dear Pavel,
> Just adding my few cents..
> I understand that you are very experienced NMUSER, so this mail
> may not
> add anything new to you.
>
>
> Error message on FNLETA comes from the posthoc step- "An error
> message
> from FNLETA indicates that NONMEM has experienced difficulties
> obtaining posthoc etas"
> Error message on CELS "usually" says that there are some "zero"
> predictions.
> So, in this way..error message makes some sense...
>
> However, i have not used IMP with M3 and Laplacian, so i can not
> comment
> on that.
>
> One thing may be...model also tries to predict the pk or pd for
> zero
> time points...that could cause this problem....if so, CALLFL=0
> in the
> $ERROR may be of some use
>
> Regards,
> Martin Johnson,
> PhD Student,
> University of Groningen,
> The Netherlands
>
>
>
> On 01/28/2011 12:31 AM, [email protected] wrote:
> > Hello Nonmem Users,
> >
> > I am getting an error message:
> > 0PROGRAM TERMINATED BY FNLETA
> > ERROR IN CELS WITH INDIVIDUAL 2 ID= 1.10050000000000E+01
> > 0VAR-COV OF SOME OBS ESTIMATED TO BE 0
> > MESSAGE ISSUED FROM TABLE STEP
> >
> > The estimate step is as follows:
> > $EST MAXEVALS=9999 SIG=5 NOABORT PRINT=1 SORT
> > METHOD=IMP CTYPE=3 NITER=1000 ISAMPLE=300 POSTHOC INTERACTION
> > MSFO=KI4H004D.MSF LAPLACIAN
> > The code also implements M3. The code runs fine, but it does
> not
> > create the output data files specified in the table
> statements. I
> > tried to remove some table statements, changed initial
> esimates, added
> > the additive component to the error model. Nothing helps.
> When I do
> > not use M3 and Laplacian, I am getting the output files. I
> used M3and
> > Laplacian with some other drugs, but I did not use it in
> combination
> > with METHOD=IMP. Can it be a NONMEM bug? The eror does not
> make sense.
> > Thanks,
> > Pavel
>
>