error message 0VAR-COV OF SOME OBS ESTIMATED TO BE 0 - a bug?
Hello Nonmem Users,
I am getting an error message:
0PROGRAM TERMINATED BY FNLETA
ERROR IN CELS WITH INDIVIDUAL 2 ID= 1.10050000000000E+01
0VAR-COV OF SOME OBS ESTIMATED TO BE 0
MESSAGE ISSUED FROM TABLE STEP
The estimate step is as follows:
$EST MAXEVALS=9999 SIG=5 NOABORT PRINT=1 SORT
METHOD=IMP CTYPE=3 NITER=1000 ISAMPLE=300 POSTHOC INTERACTION
MSFO=KI4H004D.MSF LAPLACIAN
The code also implements M3. The code runs fine, but it does not create the
output data files specified in the table statements. I tried to remove some
table statements, changed initial esimates, added the additive component to the
error model. Nothing helps. When I do not use M3 and Laplacian, I am getting
the output files. I used M3and Laplacian with some other drugs, but I did not
use it in combination with METHOD=IMP. Can it be a NONMEM bug? The eror does
not make sense.
Thanks,
Pavel