RE: Very big NONMEM

________________________________ From: [email protected] [mailto:[email protected]] On Behalf Of Rik Schoemaker Sent: Friday, 08 October, 2010 21:47 To: 'Bernard Murray'; [email protected] Subject: RE: [NMusers] Very big NONMEM Dear Bernard, What I've recently found is that increasing the size of NO to 1000 would indeed make the application too large, but by then decreasing the number of subjects (MAXIDS; in my case from 15000 to 1500), it makes the footprint manageable again. Maybe going down a factor two to 7500 would have worked as well, but I didn't spend the time on testing more combinations... Apparently NONMEM 8 will adjust the sizes dynamically, but until then we'll just have to twiddle a bit ourselves :-) Cheers, Rik Rik Schoemaker, PhD Exprimo NV Tel:+31 (0)20 4416410 E-mail: [email protected] Web: www.exprimo.com <outbind://7/www.exprimo.com> ________________________________ From: [email protected] [mailto:[email protected]] On Behalf Of Bernard Murray Sent: 08 October 2010 9:13 PM To: [email protected] Subject: RE: [NMusers] Very big NONMEM Hello there, Now that the subject of (unusually) large versions of NONMEM has been raised again, I was wondering if it is possible to increase the number of observation records per subject (NO) past the value of 500 provided in the standard "big" version of SIZES with nm7. I am working with NONMEM 7.1.2 with g95 (version 0.93!) on win32 (WinXP SP3) If I increase NO and rebuild everything (as per User Guide III 2.9.2) Windows complains ("Not a valid win32 application"). I have also tried increasing LIM1, LADD and some of the other LIM buffers. I don't know if this is a fundamental limitation or poor understanding on my part. I am actually performing simulations of a somewhat stiff system, with 6 or more DVs over long time periods (weeks). Currently I can fit things in 500 records if I am careful with the selection of timepoints but I was wondering if larger versions than "big" were possible. I have seen some discussion of this subject in previous postings but these were with nmvi or earlier. I do realise that NONMEM may not look like the best tool for this but I'd like to try fitting real world data later. Thanks for any suggestions. All the very best, Bernard Bernard Murray, Ph.D. Senior Research Scientist, Drug Metabolism Gilead Sciences, Foster City CA This message and any attachments are solely for the intended recipient. If you are not the intended recipient, disclosure, copying, use or distribution of the information included in this message is prohibited --- Please immediately and permanently delete.