RE: Very big NONMEM
Dear Bernard,
What I've recently found is that increasing the size of NO to 1000 would
indeed make the application too large, but by then decreasing the number of
subjects (MAXIDS; in my case from 15000 to 1500), it makes the footprint
manageable again. Maybe going down a factor two to 7500 would have worked as
well, but I didn't spend the time on testing more combinations...
Apparently NONMEM 8 will adjust the sizes dynamically, but until then we'll
just have to twiddle a bit ourselves :-)
Cheers,
Rik
Rik Schoemaker, PhD
Exprimo NV
Tel:+31 (0)20 4416410
E-mail: [email protected]
Web: <outbind://7/www.exprimo.com> www.exprimo.com
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Quoted reply history
From: [email protected] [mailto:[email protected]] On
Behalf Of Bernard Murray
Sent: 08 October 2010 9:13 PM
To: [email protected]
Subject: RE: [NMusers] Very big NONMEM
Hello there,
Now that the subject of (unusually) large versions of NONMEM has been raised
again, I was wondering if it is possible to increase the number of
observation records per subject (NO) past the value of 500 provided in the
standard "big" version of SIZES with nm7.
I am working with NONMEM 7.1.2 with g95 (version 0.93!) on win32 (WinXP SP3)
If I increase NO and rebuild everything (as per User Guide III 2.9.2)
Windows complains ("Not a valid win32 application"). I have also tried
increasing LIM1, LADD and some of the other LIM buffers. I don't know if
this is a fundamental limitation or poor understanding on my part.
I am actually performing simulations of a somewhat stiff system, with 6 or
more DVs over long time periods (weeks). Currently I can fit things in 500
records if I am careful with the selection of timepoints but I was wondering
if larger versions than "big" were possible. I have seen some discussion of
this subject in previous postings but these were with nmvi or earlier. I do
realise that NONMEM may not look like the best tool for this but I'd like to
try fitting real world data later.
Thanks for any suggestions.
All the very best,
Bernard
Bernard Murray, Ph.D.
Senior Research Scientist, Drug Metabolism
Gilead Sciences, Foster City CA