RE: Very big NONMEM

Hello there, Now that the subject of (unusually) large versions of NONMEM has been raised again, I was wondering if it is possible to increase the number of observation records per subject (NO) past the value of 500 provided in the standard "big" version of SIZES with nm7. I am working with NONMEM 7.1.2 with g95 (version 0.93!) on win32 (WinXP SP3) If I increase NO and rebuild everything (as per User Guide III 2.9.2) Windows complains ("Not a valid win32 application"). I have also tried increasing LIM1, LADD and some of the other LIM buffers. I don't know if this is a fundamental limitation or poor understanding on my part. I am actually performing simulations of a somewhat stiff system, with 6 or more DVs over long time periods (weeks). Currently I can fit things in 500 records if I am careful with the selection of timepoints but I was wondering if larger versions than "big" were possible. I have seen some discussion of this subject in previous postings but these were with nmvi or earlier. I do realise that NONMEM may not look like the best tool for this but I'd like to try fitting real world data later. Thanks for any suggestions. All the very best, Bernard Bernard Murray, Ph.D. Senior Research Scientist, Drug Metabolism Gilead Sciences, Foster City CA