Generating Cmax at end of infusion
Title: Paul R
G'day.
I would like to generate a concentration at the end of an infusion of
duration DUR.
I am using ADVAN3 TRANS4 with log transformed data. Here is what I
have tried, but I am getting an error that the parameter 'T' that I
understood to be the machine time is undefined. Can anyone suggest a
proper way to give set Cmax=exp(Y) at the end of the infusion of length
DUR?
Many thanks in advance.
Paul
$PK
...
TT=TIME
$ERROR
;I've also tried
;TT=TIME
;TT=T
IPRE=F
EDV=EXP(DV)
W=1
IF(F.GT.0) W=F
IRES=F-EDV
IWRE=IRES/W
LOGF=LOG(0.0001)
IF (F.GT.0) LOGF=LOG(F)
Y=LOGF+EPS(1)
;GENERATE CMAX AT END OF INFUSION (DUR)
IF(DUR.EQ.TT) CMAX=EXP(Y)
--
Paul R.
Hutson, Pharm.D.
Associate
Professor
UW School
of Pharmacy
777
Highland Avenue
Madison
WI 53705-2222
Tel 608.263.2496
Fax
608.265.5421
Pager
608.265.7000, p7856