RE: Generating Cmax at end of infusion

________________________________ From: [email protected] [mailto:[email protected]] On Behalf Of Paul Hutson Sent: Tuesday, April 06, 2010 12:12 PM To: [email protected] Subject: [NMusers] Generating Cmax at end of infusion G'day. I would like to generate a concentration at the end of an infusion of duration DUR. I am using ADVAN3 TRANS4 with log transformed data. Here is what I have tried, but I am getting an error that the parameter 'T' that I understood to be the machine time is undefined. Can anyone suggest a proper way to give set Cmax=exp(Y) at the end of the infusion of length DUR? Many thanks in advance. Paul $PK ... TT=TIME $ERROR ;I've also tried ;TT=TIME ;TT=T IPRE=F EDV=EXP(DV) W=1 IF(F.GT.0) W=F IRES=F-EDV IWRE=IRES/W LOGF=LOG(0.0001) IF (F.GT.0) LOGF=LOG(F) Y=LOGF+EPS(1) ;GENERATE CMAX AT END OF INFUSION (DUR) IF(DUR.EQ.TT) CMAX=EXP(Y) -- Paul R. Hutson, Pharm.D. Associate Professor UW School of Pharmacy 777 Highland Avenue Madison WI 53705-2222 Tel 608.263.2496 Fax 608.265.5421 Pager 608.265.7000, p7856 Notice: This e-mail message, together with any attachments, contains information of Merck & Co., Inc. (One Merck Drive, Whitehouse Station, New Jersey, USA 08889), and/or its affiliates Direct contact information for affiliates is available at http://www.merck.com/contact/contacts.html) that may be confidential, proprietary copyrighted and/or legally privileged. It is intended solely for the use of the individual or entity named on this message. If you are not the intended recipient, and have received this message in error, please notify us immediately by reply e-mail and then delete it from your system.