RE: Generating Cmax at end of infusion

Hi Paul, Is DUR modeled or explicit? If explicit then it seems as easy approach would be to include an EVID=2 record at the stated end of infusion and calculate the anti-log as you and Nick indicate. Steve Stephen C. Olson [email protected] 734 268 6867 www.clinpharmres.com From: [email protected] [mailto:[email protected]] On Behalf Of Nick Holford Sent: Tuesday, April 06, 2010 1:03 PM Cc: [email protected] Subject: Re: [NMusers] Generating Cmax at end of infusion Paul, TIME is the data record time in $PK and $ERROR. T is the time between record TIMEs in $DES. In order to use your method you need to have a record with TIME in your data set that is equal to DUR. In that case you can use this code which also sets CMAX to 0 if an individual does not have DUR.EQ.TIME. If you don't do this then you will get the CMAX from the last individual who did have DUR.EQ.TIME. IF (DUR.EQ.TIME) THEN CMAX=EXP(Y) ELSE CMAX=0 ENDIF Paul Hutson wrote: G'day. I would like to generate a concentration at the end of an infusion of duration DUR. I am using ADVAN3 TRANS4 with log transformed data. Here is what I have tried, but I am getting an error that the parameter 'T' that I understood to be the machine time is undefined. Can anyone suggest a proper way to give set Cmax=exp(Y) at the end of the infusion of length DUR? Many thanks in advance. Paul $PK ... TT=TIME $ERROR ;I've also tried ;TT=TIME ;TT=T IPRE=F EDV=EXP(DV) W=1 IF(F.GT.0) W=F IRES=F-EDV IWRE=IRES/W LOGF=LOG(0.0001) IF (F.GT.0) LOGF=LOG(F) Y=LOGF+EPS(1) ;GENERATE CMAX AT END OF INFUSION (DUR) IF(DUR.EQ.TT) CMAX=EXP(Y) -- Paul R. Hutson, Pharm.D. Associate Professor UW School of Pharmacy 777 Highland Avenue Madison WI 53705-2222 Tel 608.263.2496 Fax 608.265.5421 Pager 608.265.7000, p7856 -- Nick Holford, Professor Clinical Pharmacology Dept Pharmacology & Clinical Pharmacology University of Auckland,85 Park Rd,Private Bag 92019,Auckland,New Zealand tel:+64(9)923-6730 fax:+64(9)373-7090 mobile:+64(21)46 23 53 email: [email protected]<mailto:[email protected]> http://www.fmhs.auckland.ac.nz/sms/pharmacology/holford