Re: Generating Cmax at end of infusion

Paul, TIME is the data record time in $PK and $ERROR. T is the time between record TIMEs in $DES. In order to use your method you need to have a record with TIME in your data set that is equal to DUR. In that case you can use this code which also sets CMAX to 0 if an individual does not have DUR.EQ.TIME. If you don't do this then you will get the CMAX from the last individual who did have DUR.EQ.TIME. IF (DUR.EQ.TIME) THEN CMAX=EXP(Y) ELSE CMAX=0 ENDIF Paul Hutson wrote: > G'day. > > I would like to generate a concentration at the end of an infusion of duration DUR. I am using ADVAN3 TRANS4 with log transformed data. Here is what I have tried, but I am getting an error that the parameter 'T' that I understood to be the machine time is undefined. Can anyone suggest a proper way to give set Cmax=exp(Y) at the end of the infusion of length DUR? > > Many thanks in advance. > Paul > $PK > ... > TT=TIME > > $ERROR > ;I've also tried > ;TT=TIME > ;TT=T > IPRE=F > EDV=EXP(DV) > W=1 > IF(F.GT.0) W=F > IRES=F-EDV > IWRE=IRES/W > LOGF=LOG(0.0001) > IF (F.GT.0) LOGF=LOG(F) > Y=LOGF+EPS(1) > ;GENERATE CMAX AT END OF INFUSION (DUR) > IF(DUR.EQ.TT) CMAX=EXP(Y) > -- > > Paul R. Hutson, Pharm.D. > > Associate Professor > > UW School of Pharmacy > > 777 Highland Avenue > > Madison WI 53705-2222 > > Tel 608.263.2496 > > Fax 608.265.5421 > > Pager 608.265.7000, p7856 -- Nick Holford, Professor Clinical Pharmacology Dept Pharmacology & Clinical Pharmacology University of Auckland,85 Park Rd,Private Bag 92019,Auckland,New Zealand tel:+64(9)923-6730 fax:+64(9)373-7090 mobile:+64(21)46 23 53 email: [email protected] http://www.fmhs.auckland.ac.nz/sms/pharmacology/holford