RE: The system cannot execute the specified program
Dear Tom,
Dear All,
For those of us who prefer project specific NONMEM installations to save estimation time,
it might be helpful, if ICON can provide some rough guidance on the main contributor
to the RAM needs of NONMEM 7.
I.e. is it primarily the number of observations, compartments, thetas, omegas, or
another variable or some function of these variables?
The following might be very cumbersome: Would it be possible to include a switch
during the installation which disables certain NONMEM 7 features to save RAM.
(I recognize that this might cause a lot of unpredictable software issues.)
Dual CPU servers currently have around 8-18 RAM slots. 2 and 4 GB RAM chips are
reasonably priced. Thus, on the 64-bit server side, this is probably a minor issue.
Best wishes
Juergen
Quoted reply history
From: owner-nmusers
Behalf Of Ludden, Thomas
Sent: Friday, October 16, 2009 3:14 PM
To: nonmem
Cc: nmusers
Subject: RE: [NMusers] The system cannot execute the specified program
Pavel,
The message you describe is usually the result of not having enough memory available for the NONMEM 7 memory image. If you are using the "big" version of SIZES you may need about 1.6-2 GB of available memory for each job. For the efficient use of NONMEM 7's new methods more variables are now stored in memory than was the case for NONMEM VI. The memory image is larger even if one is not using the new methods.
When using NONMEM 7 and the "reg" SIZES, I have been able to run 8 jobs simultaneously on a dual processor dual core machine, but only 3-4 jobs when using the "big" version of SIZES depending upon what else is running. I have 3 GB of memory and the task manager indicates a maximum of about 7.4 GB via paging.
Tom
Thomas M. Ludden Ph.D.
Vice-President, Pharmacometrics R&D
ICON Development Solutions
Tel: + 1 410 696 3040
Mob: + 1 410 258 2411
Fax: + 1 410 480 0776
Email: thomas.ludden
Web: www.icondevsolutions.com
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From: owner-nmusers
Behalf Of nonmem
Sent: Friday, October 16, 2009 2:02 PM
To: nonmem
Cc: nmusers
Subject: [NMusers] The system cannot execute the specified program
> Hello NONMEM Users,
> We have a computer with 4 processors. When I try to run more
> than 3 NONMEM7 jobs, I am getting the following message:
> Starting nonmem execution ...
> The system cannot execute the specified program.
> KP9022.OUT
> newline
> 1 file(s) copied.
> Could Not Find H:\4\output
>
> The message is code and directory independent. It always
> appears when I try to run more than 3 codes. When I test
> nonmem7 using a laptop, which also has 4 processors, I can
> execute 4 programs. Also, when I had NONMEM6, I did not have
> this problem on the same machine.
> Do you familiar with this problem? Thanks.
> Pavel
>