Re: The system cannot execute the specified program
Juergen,
I'd be interested to know of your experience of how much estimation
time you save by making project specific installations. Given that you
must take additional time to setup SIZES and recompile NONMEM for each
project (say 10-15 minutes) how much time do you save per run compared
with having regular and big installations of NONMEM?
Nick
Jurgen Bulitta wrote:
Dear
Tom,
Dear
All,
For
those of us who prefer project specific NONMEM installations to save
estimation
time,
it
might be helpful, if ICON can provide some rough guidance on the main
contributor
to
the RAM needs of NONMEM 7.
I.e.
is it primarily the number of observations, compartments, thetas,
omegas, or
another
variable or some function of these variables?
The
following might be very cumbersome: Would it be possible to include a
switch
during
the installation which disables certain NONMEM 7 features to save RAM.
(I
recognize that this might cause a lot of unpredictable software issues.)
Dual
CPU servers currently have around 8-18 RAM slots. 2 and 4 GB RAM chips
are
reasonably
priced. Thus, on the 64-bit server side, this is probably a minor issue.
Best
wishes
Juergen
Quoted reply history
From:
[email protected] [ mailto: [email protected] ] On
Behalf
Of Ludden, Thomas
Sent: Friday, October 16, 2009 3:14 PM
To: [email protected]
Cc: [email protected]
Subject: RE: [NMusers] The system cannot execute the specified
program
Pavel,
The
message you describe is usually the result of not having enough
memory available for the NONMEM 7 memory image. If you are using the
"big" version of SIZES you may need about 1.6-2 GB of
available memory for each job. For the efficient use
of NONMEM 7's new methods more variables are now stored in
memory than was the case for NONMEM VI. The memory image is larger
even
if one is not using the new methods.
When
using NONMEM 7 and the "reg" SIZES, I have been able
to run 8 jobs simultaneously on a dual processor dual core machine, but
only
3-4 jobs when using the "big" version of SIZES depending upon what
else is running. I have 3 GB of memory and the task manager indicates
a
maximum of about 7.4 GB via paging.
Tom
Thomas
M. Ludden Ph.D .
Vice-President,
Pharmacometrics
R&D
ICON
Development
Solutions
Tel:
+ 1
410 696 3040
Mob: + 1 410 258 2411
Fax: + 1 410
480 0776
Email: [email protected]
Web:
www.icondevsolutions.com
From:
[email protected]
[ mailto: [email protected] ] On Behalf Of [email protected]
Sent: Friday, October 16, 2009 2:02 PM
To: [email protected]
Cc: [email protected]
Subject: [NMusers] The system cannot execute the specified
program
> Hello NONMEM Users,
> We have a computer with 4 processors. When I try to run more
> than 3 NONMEM7 jobs, I am getting the following message:
> Starting nonmem execution ...
> The system cannot execute the specified program.
> KP9022.OUT
> newline
> 1 file(s) copied.
> Could Not Find H:\4\output
>
> The message is code and directory independent. It always
> appears when I try to run more than 3 codes. When I test
> nonmem7 using a laptop, which also has 4 processors, I can
> execute 4 programs. Also, when I had NONMEM6, I did not have
> this problem on the same machine.
> Do you familiar with this problem? Thanks.
> Pavel
>