Re: The system cannot execute the specified program

----- Original Message ----- From: Nick Holford Date: Friday, October 16, 2009 11:55 pm Subject: Re: [NMusers] The system cannot execute the specified program To: nmusers > For 32 bit Windows systems with 4GB of RAM then only 2GB of RAM > is > accessible to applications. The other 2 GB is taken by the > Windows > Kernel. It is possible to give more RAM to applications using > the > boot.ini /3GB switch but this is only effective if the > applications (eg. > NONMEM) are specifically enabled to take advantage of this: > > "Executables that can use the 3-GB address space are required to > have > the bit IMAGE_FILE_LARGE_ADDRESS_AWARE set in their image > header. To set > this bit, you must use Microsoft Visual Studio Version 6.0 or > later and > the Editbin.exe utility, which has the ability to modify the > image > header (/LARGEADDRESSAWARE) flag." > > http://www.microsoft.com/whdc/system/platform/server/PAE/PAEmem.mspx > > It should be possible to run editbin after you have created a > NONMEM.exe > but before you run it. This might allow more NONMEM runs to work > on the > same machine. But I cannot find a clear statement that LAA is > helpful to > run several instances of an application or if it only helps for > one > instance. > > http://bilbroblog.com/wow64/hidden-secrets-of-w0w64-ndash-large- > address-space/ > > My limited comparisons of NONMEM 6 and NONMEM 7 indicate that > NONMEM 7 > is usually slower and may take a lot more RAM. So unless you > really need > to use a NONMEM 7 feature you will get more work done using > NONMEM 6. > > Nick > > Leonid Gibiansky wrote: > > > You may need to increase your RAM to 6GB to solve this problem. > > > > but keep in mind that on a 32-bit Windows machine it makes no > sense to > > go beyond 4 GB (computer will not be able to work with it any way). > > Leonid > > > > -------------------------------------- > > Leonid Gibiansky, Ph.D. > > President, QuantPharm LLC > > web: www.quantpharm.com > > e-mail: LGibiansky at quantpharm.com > > tel: (301) 767 5566 > > > > > > > > > > Sam Liao wrote: > >> According to ICON, this is due to the size of the RAM on your > PC. If > >> you have less than 3 GB of RAM and running the ‘big’ nm7 job, > it will > >> not allow you to run more than 2 jobs at once. You may need > to > >> increase your RAM to 6GB to solve this problem. > >> > >> > >> > >> Best regards, > >> > >> Sam Liao > >> > >> Pharmax Research > >> > >> > >> > >> *From:* [email protected] > >> [mailto:[email protected]] *On Behalf Of > >> *[email protected] > >> *Sent:* Friday, October 16, 2009 2:02 PM > >> *To:* [email protected] > >> *Cc:* [email protected] > >> *Subject:* [NMusers] The system cannot execute the specified > program>> > >> > >> > >> > Hello NONMEM Users, > >> > We have a computer with 4 processors. When I try to run more > >> > than 3 NONMEM7 jobs, I am getting the following message: > >> > Starting nonmem execution ... > >> > The system cannot execute the specified program. > >> > KP9022.OUT > >> > newline > >> > 1 file(s) copied. > >> > Could Not Find H:\4\output > >> > > >> > The message is code and directory independent. It always > >> > appears when I try to run more than 3 codes. When I test > >> > nonmem7 using a laptop, which also has 4 processors, I can > >> > execute 4 programs. Also, when I had NONMEM6, I did not have > >> > this problem on the same machine. > >> > Do you familiar with this problem? Thanks. > >> > Pavel > >> > > >> > > -- > Nick Holford, Professor Clinical Pharmacology > Dept Pharmacology & Clinical Pharmacology > University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, > New Zealand > [email protected] tel:+64(9)923-6730 fax:+64(9)373-7090 > mobile: +64 21 46 23 53 > http://www.fmhs.auckland.ac.nz/sms/pharmacology/holford > >