RE: ETA on ALAG1
Dear Ayyappa,
You may find the following link useful it suggests that a mixture model may be
helpful to estimate ETAS:
Estimating Variability of Infusion Rate or Duration and Lag Time Using Mixture
Models
J. Ahn, T. Ludden
http://www.aapsj.org/abstracts/AM_2007/AAPS2007-000939.PDF
Bests,
Samer
Quoted reply history
-----Original Message-----
From: [email protected] on behalf of [email protected]
Sent: Fri 12/12/2008 16:00
To: [email protected]
Subject: [NMusers] ETA on ALAG1
Dear All,
It is an old topic, but definetely not completely resolved. Can anybody
provide tips on estimating variability on ALAG1 in a 2 comp, oral
absorption model (I am using NONMEM V). I am getting an error message
OBJFUN is negative. I have searched in usernet archive but could not
solve the problem. I appreciate your help.
Regards,
Ayyappa Chaturvedula
GlaxoSmithKline
1500 Littleton Road,
Parsippany, NJ 07054
Ph:9738892200