RE: ETA on ALAG1

Hello, The easy fix is to use the Hybrid option. See this posting: http://www.cognigencorp.com/nonmem/nm/99jun022003.html http://www.cognigencorp.com/nonmem/nm/99jun022003.html The key messages are at the very end of this thread: "....you might try the hybrid method specifying that the eta for tlag is approximated by FO while the others use FOCE. See NONMEM Guide VII, pp 14-15." "....Thanks for the suggestion, you have no idea how much my day gets improved by a MINIMIZATION SUCCESSFUL." The more elegant solution (but will take time due to the use of $DES) is to use the transit compartment absorption model. You can look up Dr. Savic's or Dr. Wilkin's presentation on the PAGE website or see Dr. Savic's paper. http://www.page-meeting.org/?abstract=513 http://www.page-meeting.org/?abstract=513 http://www.page-meeting.org/?abstract=1113 http://www.page-meeting.org/?abstract=1113 http://www.springerlink.com/content/wm7763462310778q/ Good luck, Mahesh