Re: ETA on ALAG1

As Nick said you could have a negative objective function that is not an error. Usually estimating an ETA on lag time could be problematic; however you could use the hybrid method in NM. Please see the NM help files for more details. *Nidal AL-Huniti, PhD* *Associate Director, Modeling and Simulations * *ICON Development Solutions * On 12/12/08, Nick Holford <n.holford > > Ayyappa, > > It is not an error to have a negative objective function value. > > It is an error not to describe the problem accurately. > If you want to get help from nmusers then please quote the EXACT wording of > the error message and describe what you did that caused the error to appear. > > Nick > > ayyappa.5.chaturvedula > >> >> Dear All, >> >> It is an old topic, but definetely not completely resolved. Can anybody >> provide tips on estimating variability on ALAG1 in a 2 comp, oral absorption >> model (I am using NONMEM V). I am getting an error message OBJFUN is >> negative. I have searched in usernet archive but could not solve the >> problem. I appreciate your help. >> >> Regards, >> Ayyappa Chaturvedula >> GlaxoSmithKline >> 1500 Littleton Road, >> Parsippany, NJ 07054 >> Ph:9738892200 >> > > -- > Nick Holford, Dept Pharmacology & Clinical Pharmacology > University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New > Zealand > n.holford > http://www.fmhs.auckland.ac.nz/sms/pharmacology/holford > >