Re: ETA on ALAG1

Ayyappa, It is not an error to have a negative objective function value. It is an error not to describe the problem accurately. If you want to get help from nmusers then please quote the EXACT wording of the error message and describe what you did that caused the error to appear. Nick [email protected] wrote: > Dear All, > > It is an old topic, but definetely not completely resolved. Can anybody provide tips on estimating variability on ALAG1 in a 2 comp, oral absorption model (I am using NONMEM V). I am getting an error message OBJFUN is negative. I have searched in usernet archive but could not solve the problem. I appreciate your help. > > Regards, > Ayyappa Chaturvedula > GlaxoSmithKline > 1500 Littleton Road, > Parsippany, NJ 07054 > > Ph:9738892200 -- Nick Holford, Dept Pharmacology & Clinical Pharmacology University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand [email protected] tel:+64(9)923-6730 fax:+64(9)373-7090 http://www.fmhs.auckland.ac.nz/sms/pharmacology/holford