Re: dataset codification

Susan, NM-TRAN's translation of DATE and TIME is a critical part of the system. If you have found a problem then I encourage you to report the details to nmconsult <[EMAIL PROTECTED]> so that it can be investigated. Willavize, Susan A wrote: > Note I do not include DATE and clock TIME in my NONMEM input, since I have seen NONMEM do nefarious things with these. Sebastian, Sébastien Bihorel wrote: > You are right Susan: the Time values have to increase within a subject. Using EVID=4 allows you to use a more convenient time scale In general I try to avoid using EVID=4 because it requires the assumption of complete washout from previous doses. The convenience of every dose starting at time zero may be offset by the inconvenience of getting the wrong parameter estimates. Nick -- Nick Holford, Dept Pharmacology & Clinical Pharmacology University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand [EMAIL PROTECTED] tel:+64(9)923-6730 fax:+64(9)373-7090 http://www.fmhs.auckland.ac.nz/sms/pharmacology/holford