RE: dataset codification
I have seen EVID=4 used, but don't remember the details. How does the time
variable look? I always convert Date and time to a time counting variable that
starts at 0 time (time of first dose) and always increases within each subject.
I recall that when EVID= 4 is used, the time variable does NOT need to restart
with the second dose. Do I remember correctly?
Note I do not include DATE and clock TIME in my NONMEM input, since I have seen
NONMEM do nefarious things with these.
Susan
Quoted reply history
________________________________
From: [EMAIL PROTECTED] [mailto:[EMAIL PROTECTED] On Behalf Of Sébastien Bihorel
Sent: Wednesday, September 24, 2008 5:52 AM
To: Mark Gutierrez
Cc: [email protected]
Subject: Re: [NMusers] dataset codification
Dear Mark,
You may want to read about "EVID" in the html help. EVID = 4 is what you mean.
It is a dosing event but implies that the system is reset before the dose is
introduced into the system.
Sebastien
Mark Gutierrez a écrit :
Dear all,
I am modeling some PK data from one rabbit. And I have some doubts how to
codify the dataset. The rabbit received different single doses of a drug at
different times.
E.g,
First of May it received a 100 mg dose i.v. ,
Then, 2 months latter (enough washout period), the first of July, it received
and oral dose of 100mg..
Finally, after other two months the rabbit received the last oral dose 200mg.
I could codify in the TIME column the real times, including the jumps of two
months, but I think that there is an option in Nonmem to "restart" the dose
through the dataset.
Could somebody clarify me this point? and perhaps include a simple example of
dataset.
Thank you in advance
Mark