Re: GAM analysis and further action

From: "Gastonguay, Marc" marcg@metrumrg.com Subject: Re: [NMusers] GAM analysis and further action Date: Wed, 29 Mar 2006 16:01:36 -0500 Dennis - We'd probably all agree that modeling results are not effective unless presented in a useful clinical perspective. This doesn't mean that we have to use a less than adequate model, though. In fact, it has been shown that this can lead to biased interpretation of other model components (Wade et al J Pharmacokinet Biopharm 1994; 22(2):165-77). As Manish suggested, this is definitely a concern in pediatrics when body-size and age-dependent changes in physiology are correlated. We can actually meet both goals; build models that are structurally consistent with known physiology and observed data and then use these models as simulation tools to explore the impact of simpler clinical guidance. Best regards, Marc Marc R. Gastonguay, Ph.D. www.metrumrg.com