GAM analysis and further action
From: Dennis Fisher fisher@plessthan.com
Subject: [NMusers] GAM analysis and further action
Date: Wed, 29 Mar 2006 11:47:40 -0800
Manish suggested a allometric model. Although this approach MIGHT be appropriate from a
PHYSIOLOGIC perspective, I truly doubt that it is helpful from a CLINICAL perspective. If we report
that CL varies as a function of weight^0.75, what clinician will be able to use this information to
guide dosing? So, I prefer to define models in terms that can be useful in the clinical setting.
Dennis Fisher MD
P < (The "P Less Than" Company)
Phone: 1-866-PLessThan (1-866-753-7784)
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