RE: Incorporating duplicate assays

From: "Piotrovskij, Vladimir [PRDBE]" VPIOTROV@PRDBE.jnj.com Subject: RE: [NMusers] Incorporating duplicate assays Date: Fri, 18 Nov 2005 10:14:28 +0100 Matt, I don't think there is any correlation in the case of duplicated assays. In the model Yijk = Fij * (1 + ETAij + ETAijk) higher ETAij is not necessarily accociated with systematically higher (or lower) ETAijk. I do not see any reason of using L2 data item. The situation is completely different compared to the parent-metabolite correlation you mention. There are here 2 analytes. BTW, an example of using L2 presented in the NONMEM user guide V includes simultaneous analysis of PK and PD data; it is also an example of 2 types of observations that may indeed correlate. Best regards, Vladimir