RE: MIXTURE modeling

From: "Bruce Green" greenb@pharmacy.uq.edu.au Subject: RE: [NMusers] MIXTURE modeling Date: Fri, 18 Nov 2005 09:52:22 +1000 Hi Joern, Mixture models can be useful if you can clearly identify two subpopulations by just looking at the data. However, relying on the dOBJ as a diagnostic for the presence of a mixture is probably not a good idea, especially if you are using the FO method. We identified that the delta OBJ might be really large (in the magnitude of thousands) to reject the null. Which method in NONMEM are you using, what sort of error structure do you have? Cheers, Bruce _______________________________________________________