Re: non-linear PK

From: Kenneth Kowalski Date: October 06, 2005 technical Source: cognigencorp.com
From: "Kowalski, Ken" Ken.Kowalski@pfizer.com Subject: Re: [NMusers] non-linear PK Date: Thu, 6 Oct 2005 13:05:35 -0400 Leonid, I think W is correctly specified in Jing's control stream below. As she has coded it, W is the residual standard deviation (given the ETAs) for the combined proportional and additive error model. That is, Var(Y | ETAs) = (W2)Var(ERR(1)) = W2 = THETA(8)**2 + (THETA(9)**2)*F*F where THETA(8) is the residual SD for the additive component and THETA(9) is the residual CV for the proportional component. Ken

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Oct 06, 2005 Jing Li non-linear PK
Oct 06, 2005 Leonid Gibiansky Re: non-linear PK
Oct 06, 2005 Brenda Cirincione Re: non-linear PK
Oct 06, 2005 Juan Jose Perez Ruixo Re: non-linear PK
Oct 06, 2005 Kenneth Kowalski Re: non-linear PK
Oct 06, 2005 Leonid Gibiansky Re: non-linear PK
Oct 06, 2005 Paul Hutson Re: non-linear PK
Oct 06, 2005 Toufigh Gordi Non-linear CL
Oct 06, 2005 Jing Li Re: Non-linear CL
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