Re: Non-linear CL

From: "Jing Li" jli29@jhmi.edu Subject: Re: [NMusers] Non-linear CL Date: Thu, 06 Oct 2005 16:47:51 -0400 Hi, Thanks very much for everyone's input! As you pointed out, I fixed the problems with $DES and Error model, and changed subroutine of advan9 to advan6 in my control stream. Also, I reduced the number of ETAs. The model is running, looks promising. The drug shows a concentration- and dose-dependent CL, as well as a concentration-dependent protein binding. That means, the unbound fraction changes with time (with highest unbound fraction at the end of infusion). I also have unbound concentrations. So, eventually, I will fit the total and unbound concentration simultaneously, with a link of a non-linear protein binding function. Best regards. Jing _______________________________________________________