Re: non-linear PK

From: Paul Hutson prhutson@pharmacy.wisc.edu Subject: Re: [NMusers] non-linear PK Date: Thu, 06 Oct 2005 12:20:29 -0500 Jing: From a first look: 1) your central compartment (1) does not appear to reflect the return from compartment 2 DADT(1) = - K12*A(1) - A(1)*VM/(KM+C1)+ K21*A(2) 2) your saturable term should use C1 instead of A(1) in order to yield units of mass/time. 3) Is there a reason you are setting this up to have no exchange between compartment 1 and 3? Paul > > $DES > C1 = A(1)/V1 > DADT(1) = - K12*A(1) - A(1)*VM/(KM+C1) > DADT(2) = K12*A(1) - K21*A(2) + K32*A(3) - K23*A(2) > DADT(3) = K23*A(2) - K32*A(3) > > -- Paul R. Hutson, Pharm.D. Associate Professor UW School of Pharmacy 777 Highland Avenue Madison WI 53705-2222 Tel 608.263.2496 Fax 608.265.5421 Pager 608.265.7000, p7856