RE: Plcebo Corrected PK/PD

From: "Bhattaram, Atul" BhattaramA@cder.fda.gov Subject: RE: [NMusers] Plcebo Corrected PK/PD Date: Fri, March 4, 2005 4:05 pm Hello Nick I dont think you can estimate the "true variability" unless one does a cross-over design. If you dont have placebo data in the same subject for symptomatic drugs (anti-hypertensives) how would you estimate the "true variability"?. Venkatesh Atul Bhattaram Pharmacometrics, FDA