RE: Plcebo Corrected PK/PD
From: "Bachman, William (MYD)" bachmanw@iconus.com
Subject: RE: [NMusers] Plcebo Corrected PK/PD
Date: Fri, March 4, 2005 4:23 pm
This is done all the time (measure the placebo effect in some subjects and
the drug effect in others (- at least where ethical). Look at all those
analgesic studies that have been done. It's clear you don't have the
variability in the "same" subjects, but, in a well designed study with
sufficient power the estimate of variability in placebo effect is
sufficiently accurate for the purpose. In many cases, there is no other way
to do it. Obviously, the study design is dependent on the indication,
severity of disease state and practicality/ethicality (you can't pull teeth
from a subject without medication one week and with medication the next).