Re: Plcebo Corrected PK/PD

From: "Nick Holford" n.holford@auckland.ac.nz Subject: Re: [NMusers] Plcebo Corrected PK/PD Date: Fri, March 4, 2005 5:47 pm Atul, It all depends on the model you have in mind. If the time course of the placebo effect is essentially the same as the time course of the drug effect then I agree that the two components of the overall response cannot be distinguished (as I indicated in my previous posting). But if the placebo response (or disease progress) is different from the time course of drug effect then the components should be identifiable. Nick -- Nick Holford, Dept Pharmacology & Clinical Pharmacology University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand email:n.holford@auckland.ac.nz tel:+64(9)373-7599x86730 fax:373-7556 http://www.health.auckland.ac.nz/pharmacology/staff/nholford/