RE: $OMEGA blocks and log-likelihood profiling

From: Nick Holford n.holford@auckland.ac.nz Subject: RE:[NMusers] $OMEGA blocks and log-likelihood profiling Date: Thu, June 10, 2004 4:57 pm Leonid, Thank you for your further comments. I am afraid your guess is wrong. The model (a "strongly failed NONMEM run") which is the subject of this discussion has indeed been published in Br J Clin Pharmacol. http://www.blackwell-synergy.com/links/doi/10.1111/j.1365-2125.2004.02114.x/ I can assure you many tricks and initial estimate games were played to try and get a cleaner solution for this model. If you have read the previous discussion you will realize that the *model* can describe a random sample of the original data with successful minimization and $COV. So my contention is that this is not a model problem but a modelling program (NONMEM) problem. I invite you to write to the editor with your opinions if you wish but I would prefer to read some arguments based on data. Nick -- Nick Holford, Dept Pharmacology & Clinical Pharmacology University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand email:n.holford@auckland.ac.nz tel:+64(9)373-7599x86730 fax:373-7556 http://www.health.auckland.ac.nz/pharmacology/staff/nholford/