RE: Fx

From: Ekaterina Gibiansky GibianskyE@guilfordpharm.com Subject: RE: [NMusers] Fx Date: Tue, May 25, 2004 5:03 pm Paul, I feel, with our sloppy explanations we do not make your life easier. Nick is right, F1, not F2, is what we are talking about. F2 would only be defined if you place a dose directly in compartment 2. With dose placed in compartment 1, only F1 make sense, and it is AMT*F1 what NONMEM sees in compartment 1. With your example F1=0.42, if your AMT is the total dose administered, and F1=0.7 if you manage to subtract the unreleased dose from your AMT in the data file. As to using V2 in $DES, I do not see any problem there as long as you keep units consistent for all parameters. From the two solutions of dealing with metabolite bioavailability, assuming everything is going into compartment 3 (i.e. forget about CLM) versus fixing V3=V2 (like you have), I would prefer the former only because it can not create a false impression of knowledge of fraction metabolized. Katya *-------------------- Ekaterina Gibiansky, PhD Head, Pharmacometrics & Principal Scientist Guilford Pharmaceuticals Inc Phone: (410)-631-6828 Fax: (410)-631-6828 E-mail: gibianskye@guilfordpharm.com