RE: Fx

From: Bachman, William (MYD) bachmanw@iconus.com Subject: RE: [NMusers] Fx Date: Tue, May 25, 2004 2:34 pm F2 is the fraction of "the DOSE that enters into CMT2" that would be "available" for transfer into a subsequent compartment (not "the fraction of the DOSE in the CMT1 depot compartment (AMT*F1) that enters CMT2", that's F1). Nick's points on identifiability with respect to parent-metabolite modeling are also well taken. I don't believe I would try to model F2 personally in this situation unless I could separately administer the metabolite. Even then ... However, I don't quite follow his logic about the use of V2 in $DES (units of CL/V are inverse time, so you end up with amount per time.) And it allows you to parameterize the model in terms of useful parameters. William J. Bachman, Ph.D. Manager, Pharmacometrics Research and Development GloboMax The Strategic Pharmaceutical Development Division of ICON plc 7250 Parkway Drive, Suite 430 Hanover, MD 21076 410-782-2212 bachmanw@iconus.com