RE: Fx

From: Bachman, William (MYD) bachmanw@iconus.com Subject: RE: [NMusers] Fx Date: Tue, May 25, 2004 7:51 am F2 must be explicitly included: TVCL=THETA(1) TVV=THETA(2) F2=THETA(3) V2=TVV S2=V2/1000 (also, remember that, the volume AND the clearance are both apparent, if you don't include F2) With respect to " should the parameter V2 or S2 be used in the differential (or, adjusting for the 10^3 difference, does it matter?)...": They have different functions, S2 should be defined in $PK because it converts the second compartment amounts to concentrations (NONMEM calculates amounts whereas we generally observe concentrations). V2 or S2 can be used in $DES (IF THERE WAS NOT ALSO A UNIT ADJUSTMENT FACTOR) because they WOULD be equivalent (and are used to calculate the rate constant needed in the differential equation, CL/V2.) William J. Bachman, Ph.D. Manager, Pharmacometrics Research and Development GloboMax The Strategic Pharmaceutical Development Division of ICON plc 7250 Parkway Drive, Suite 430 Hanover, MD 21076 410-782-2212 bachmanw@iconus.com