RE: ERROR: ABSORPTION LAG IS GREATER THAN OR EQUAL TO STEADY STATE DOSE INTERVAL

From: VPIOTROV@PRDBE.jnj.com Subject: RE: [NMusers] ERROR: ABSORPTION LAG IS GREATER THAN OR EQUAL TO STEADY STATE DOSE INTERVAL Date: 1/6/2004 10:49 AM David, You may try constraining individual ALAG using logit-logistic transformation. I think in your case individual ALAG can hardly exceed 1 hr, so the following may work: .. TALAG = THETA(.) LOGIT = LOG(TALAG/(1-TALAG)) ALAG1 = EXP(TALAG+ETA(.))/(1+EXP(TALAG+ETA(.))) .. THETA(.) should have boundaries like (0,.1,1) Hope this helps. Vladimir ----------------------------------------------------------------- Vladimir Piotrovsky, Ph.D. Research Fellow, Advanced PK-PD Modeling & Simulation Global Clinical Pharmacokinetics and Clinical Pharmacology Johnson & Johnson Pharmaceutical Research & Development B-2340 Beerse Belgium _______________________________________________________