RE: Describing variability

From:"Bhattaram, Atul" Subject:RE: [NMusers] Describing variability Date:Thu, 27 Mar 2003 08:50:00 -0500 Hello Justin Wilkins You can combine all the information from different studies and analyse by one model. Since you say you have "rich" data you can use FOCE or FOCE+INTERACTION. I would look at the histograms of the pk parameters and see if the two groups (healthy and patients) are different. Then you add the interoccasion variability (IOV)and check the variability estimates. Doing stepwise will always help you to figure out the importance of each step in model building. Venkatesh Atul Bhattaram CDER, FDA.