Describing variability

From: "Justin Wilkins" Subject: [NMusers] Describing variability Date:Thu, 27 Mar 2003 15:10:33 +0200 Hi all, I'm working on the pharmacokinetics of rifampicin in different populations (3 sets of patients from different sites and times, and one group of healthy volunteers) with a view to describing the extent to which those populations differ from one another. This means I'll have to focus on IIV and IOV components in my analysis, rather than simple PK parameters. Does anyone have any suggestions about how to approach this in practice? I'm using the richest patient group as a starting point for model building in NONMEM. If you reply, please note that I'm a relative beginner in population PK! Best regards Justin Wilkins Tuberculosis Research Unit Division of Pharmacology Department of Medicine Faculty of Health Sciences University of Cape Town --------------------------- K45 Old Main Building Groote Schuur Hospital Observatory 7925 South Africa Tel: +27 21 406 6659 Fax: +27 21 448 1989 Email: jwilkins@uctgsh1.uct.ac.za http://www.uct.ac.za/depts/pha --- Outgoing mail is certified Virus Free. Checked by AVG anti-virus system ( http://www.grisoft.com ). Version: 6.0.463 / Virus Database: 262 - Release Date: 2003/03/17