RE: metabolite modeling

Date: Thu, 9 Dec 1999 10:53:43 -0600 From: David_Bourne <david-bourne@ouhsc.edu> Subject: RE: metabolite modeling >I am not sure that the model is structurally unidentifiable. If >concentration-time data exists for the parent and for the metabolite, all >parameters should be unique. My reasoning is as follows: All parameters ...snip >Without additional data you have two choices: 1) set K20=0 >(ie all drug is converted to metabolite) then K24 and V4 >would both then be individually globally identifiable; or 2) >fix V4=V2 then you would be ok. The additional needed data is drug and metabolite amounts excreted into urine. Total amounts are the minimum needed. See http://www.boomer.org/course/pk_bio/Ch9906b/index.htm for more information. ;-) David