RE: metabolite modeling
Date: Fri, 10 Dec 1999 12:34:05 -0500
From: Sandra R B Allerheiligen <ALLERHEILIGEN_SANDRA_R_B@Lilly.com>
Subject: RE: metabolite modeling
Hi Matt
We have simulatanous analyzed a number of parent and metabolite profiles. I am not clear how you could get meaningful parameter estimates for the metabolite without simultaneously fitting the parent concentrations in addition to having some way on knowing the fraction of parent molecule clearance that reflects the formation rate.
Regards
Sandy A