RE: Covariate Models Using Weight
From: "Piotrovskij, Vladimir [JanBe]" <VPIOTROV@janbe.jnj.com>
To: nmusers@c255.ucsf.edu
Subject: RE: Covariate Models Using Weight
Date: Tue, 23 Nov 1999 08:41:03 +0100
MIME-Version: 1.0
I agree that having parameters of pre-defined formulas open for iterations
may improve the fit, and this is perhaps a reasonable approach if a drug is
eliminated exclusively via passive glomerular filtration. However, if the renal clearance is only a part of the total clearance, and the enzyme-dependent part may be affected by the same covariates (AGE, WT, etc.) differently, this approach will not work or will give misleading results.
Vladimir
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Vladimir Piotrovsky, Ph.D.
Janssen Research Foundation
Clinical Pharmacokinetics
B-2340 Beerse
Belgium
Email: vpiotrov@janbe.jnj.com