Re: Covariate Models Using Weight

Date: Thu, 18 Nov 1999 10:04:51 +0000 From: James <J.G.Wright@ncl.ac.uk> Subject: Re: Covariate Models Using Weight Dear Nick, Just to make this clear - if I put on weight ie fat tissue, my clearance increases? How? Does my liver get bigger? I shall read your selected references (again, as I have read two of them in the past, although asking me to read a book before considering my views seems a little demanding), but given that only two of them appear to be about clinical populations, I can hardly consider this an overwhelming body of evidence. Can I suggest that you take a look at? Nawaratne S. Brien JE. Seeman E. Fabiny R. Zalcberg J. Cosolo W. Angus P. Morgan DJ. Relationships among liver and kidney volumes, lean body mass and drug clearance. British Journal of Clinical Pharmacology. 46(5):447-52, 1998 Nov James