Re: Covariate Models Using Weight

From: "Stephen Duffull" <sduffull@fs1.pa.man.ac.uk> Subject: Re: Covariate Models Using Weight Date: Mon, 22 Nov 1999 17:04:44 -0000 James Gallo wrote (in relation to a comment from Nick): > I feel you also are missing my point about covariate modeling related to > renal function or any other mechanism related to drug disposition. For > some reason you seem to want to adhere to PRE-DEFINED Formulas to describe > CRCL and subsequently drug clearance. This was my original point. If there is little difference in the fit between two models (one "predefined" and one not) to the same data then incorporating the "predefined" model which has proven generality seems more mechanistic than developing a "context-sensitive" model empirically (which has unknown generality). The choice of the "predefined" model (or "context-insensitive" model) is then up to the modeller (obviously no one model is going to solve all problems). Steve ===================== Stephen Duffull School of Pharmacy University of Manchester Manchester, M13 9PL, UK Ph +44 161 275 2355 Fax +44 161 275 2396