Re: NONMEM and identification of drug-drug interactions

From: "Dr Ziad Hussein" <ziadh@fs1.pa.man.ac.uk> Subject: Re: NONMEM and identification of drug-drug interactions Date: 17 Dec 1997 12:51:48 -0500 I was involved in the population PK of 2 different drugs where we looked at drug-drug interaction. For lamotrigine, we examined any interaction with oral contraceptives. The outcome was negative- not interaction [Z. Hussein & J. Posner. Br J Clin Pharmacol 1997; 43:457-465]. For atovaquone, we examined any possible interaction with proguanil (chloroguanide), pyrimethamine and tetracycline. Also in this case there was no drug-drug interaction [Hussein et al. Clin Pharmacol Ther 1997; 61:518-30]. Also, reference is made to the talk about this topic by Professor Tom Ludden, University of Nebraska, at the last COST meeting in Geneva. A book with all oral and poster presentations was sent to all participants. Dr Ziad Hussein Centre for Applied Pharmacokinetic Research The University of Manchester Oxford Road Manchester M13 9PL United Kingdom