Re: Drug Interactions

From: Cornelia Weber Date: December 19, 1997 technical Source: cognigencorp.com
From: Cornelia Weber 41 61 68 88017 <CORNELIA.WEBER@roche.com> Subject: Re: Drug Interactions Date: 19 Dec 1997 08:30:31 -0500 I am planning to include the evaluation of drug-drug-interactions in the population PK analysis of two phase III trials. I would like to group concomitant medications into groups such as e.g. CYP3A4 inhibitors, CYP2C9 substrates, CYP2C9 inducers etc. based on the fact that "my" drug of interest is a CYP3A4 and CYP2C9 substrate. Does anybody has experience with such an approach? Wouldn't that make more sense from a scientific point of view than using classes like diuretics or Ca-antagonists? It might well be that the majority of drugs in such a class has the same elimination pathway. But there are cases where one or more drugs in such a class have an elimination pathway which differs from that of the others? If the mentionned approach is used would you still propose to also investigate the data using the other approach of coding drugs into groups in parallel? Thanks for your answers in advance. Conni Weber Clinical Pharmacology Hoffmann-La Roche Base, Switzerland

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Dec 16, 1997 Gary Maier NONMEM and identification of drug-drug interactions
Dec 17, 1997 Janet Wade Drug Interactions
Dec 17, 1997 Mats Karlsson Re: NONMEM and identification of drug-drug interactions
Dec 17, 1997 Rene Bruno NONMEM and drug-drug interaction
Dec 17, 1997 Ziad Hussein Re: NONMEM and identification of drug-drug interactions
Dec 17, 1997 Ekaterina Gibiansky RE: NONMEM and identification of drug-drug interactions
Dec 19, 1997 Mats Karlsson RE: NONMEM and identification of drug-drug interactions
Dec 19, 1997 Ziad Hussein RE: NONMEM and identification of drug-drug interactions
Dec 19, 1997 Cornelia Weber Re: Drug Interactions
Dec 19, 1997 Mats Karlsson Re: Drug Interactions
Dec 19, 1997 Ekaterina Gibiansky RE: NONMEM and identification of drug-drug interactions
Dec 19, 1997 Robert Shore Re: Drug Interactions
Dec 19, 1997 Jeff Wald Re: Drug Interactions
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