NONMEM and identification of drug-drug interactions

From: Gary Maier <S=Maier%C=US%G=Gary%O=ELFSANOFI%OU1=PA01%ELF21@mcimail.com> Subject: NONMEM and identification of drug-drug interactions Date: 16 Dec 1997 14:58:00 -0500 Hello, Recently I attended a meeting where two somewhat different viewpoints on the use of population PK in assessing drug-drug interactions were presented. As I am faced with this situation at Sanofi, I was wondering if you could take the time and let me and the user community know what experience you have had in using population PK to identify possible drug-drug interactions and describe the limiting situations you may have experienced. Are there any circumstances under which you would advocate the use of population PK to test hypothesized interactions or would you resort to more traditional designs Under what circumstances did you for example encounter either false positive or negative results thanks in advance for your help in this matter, Gary Maier Sanofi