RE: Re[2]: kinetic interpolation and effect compartments

From LIAO@cosmos.prius.jnj.com Wed Sep 25 08:48:50 1996 Subject: RE: Re[2]: kinetic interpolation and effect compartments Kyungsoo: You may recall that I had asked if you can use the CLS in $DES block couple weeks ago. I am not sure the NONMEM example you gave will work. Basically, this is a hybrid model (a mixture of integrated and differential equations). In order to solve these equations, we need to define Cp(t) at each step of numerical integration of DF. Usually this step is much smaller than the PK/PD sampling interval. Can your CLS provide this Cp(t) in $DES? If you have CLS estimate prior to $DES, the Cp(t) is only defined at each observed time point.