kinetic interpolation and effect compartments

From rs@chdr.leidenuniv.nl Tue Sep 24 00:50:01 1996 Subject: kinetic interpolation and effect compartments I'm running into the following problem. I'd like to do PK/PD modelling for a benzodiazepine that has been administered orally. However kinetics are rather irregular (deviations from simple first or zero-order absorption) making a good description/interpolation of the kinetic profile impossible using standard pharmacokinetic models. After glancing over the nice work of Kyungsoo Park et al I wondered if something like constrained longitudinal splines could work in this case as well. I feel I may have to resort to an effect compartment so I need some sort of continuous interpolation to feed into my compartment. I was hoping this is all clear cut for someone out there! If not, I welcome any suggestions. Regards, Rik Schoemaker, CHDR, Leiden, NL