recursive PRED
From R.Port@dkfz-heidelberg.de Fri Sep 27 03:47:36 1996
Subject: recursive PRED
Rik Schoemaker's message of Sept 26
My message of Sept 27 including this idea for a recursive $PRED
> IF (TIME.EQ.0) Celast = 0 ; or some other initial value
> Cenew = ... Celast ... (function of Celast and the PK parameters)
> effect = ... (function of Cenew and more parameters
> Y = ... effect ... EPS( )
> Celast = Cenew
Alison's message of Sept 26
My message of Sept 27
> Hi Alison,
>
> Thanks to your comment I see that the above code won't work with population
> data, at least when the FO method is used. I'm wondering whether it could be
> applicable with the FOCE method. What is your answer?
Hi Alison,
of course, for FOCE, I was thinking of a code that includes eta's:
IF (TIME.EQ.0) Celast = 0 ; or some other initial value
Cenew = ... Celast ... (function of Celast,
the mean population PK parameters, and some eta's)
effect = ... (function of Cenew, more parameters (more eta's))
Y = ... effect ... EPS( )
Celast = Cenew
What do you think?
Thanks! Ruedi
-------------------------------------------------------------------------------
R.E. Port, Dept. 0420, German Cancer Research Center
P.O. Box 10 19 49, D-69009 Heidelberg
phone: x49-6221 42-3385
-3347
fax: -3346
e-mail: r.port@dkfz-heidelberg.de