Re: kinetic interpolation and effect compartments

From n.holford@auckland.ac.nz Wed Sep 25 16:06:15 1996 Subject: Re: kinetic interpolation and effect compartments Sam (and interested nmusers) > > Nick: > > I am interested in your cubic spline interpolation for PK/PD > modeling. Do you mind provide your NONMEM control stream file to > the Stanford's NONMEM repository ? (Adress: > ftp://pkpd.icon.palo-alto.med.va.gov/public/) Thanks! > > I had asked Kyungsoo if it is possible to use CLS in $DES, he said > no. There must be some way to implement this. > > Sam Liao > The cubic spline interpolation of PK for use with an effect compart model is implemented in MKMODEL. It is not a part of NONMEM. I have not yet heard from Kyungsoo about using CLS in $DES although I posted this question yesterday to nmusers. Did you see the question? -- Nick Holford, Dept Pharmacology & Clinical Pharmacology University of Auckland, Private Bag 92019, Auckland, New Zealand email:n.holford@auckland.ac.nz tel:+64(9)373-7599x6730 fax:373-7556 http://www.phm.auckland.ac.nz/Staff/NHolford/nholford.html