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From: Subject: Date: > The $INPUT control stream read the following: > $INPUT ID TIME AMT RATE DV SEX WT PART EV1=DROP EV2=DROP EV3=DROP EV4=EVID > EV5=DROP EV6=DROP > So, by toggling on and off the EVx=EVID/DROP, I hoped to get my desired > evaluation. > It did not work since the nm-tran reported for the data records of study > parts that were flagged out: > THE DV DATA ITEM IS POSITIVE, BUT THE MDV DATA ITEM IS 1 > I did not specify a MDV data item, so this must refer to a 'generated MDV'. When I have seen this it is a WARNING not an ERROR. NM-TRAN generates the warning but NONMEM should still be able to run and will ignore these records. You can turn off WARNINGS with this record: $WARNINGS NONE if the warning messages interfere with your enjoyment of running NONMEM. You do pay a price by making NONMEM do extra work moving useless data around but that is up to you. I would personally prefer to create sub-sets of data from the one you have that contain just the records you need. I typically do tens or hundreds of runs on a single data set so dont see the point of having the extra data overhead. Nick -- Nick Holford, Divn Pharmacology & Clinical Pharmacology University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand email:n.holford@auckland.ac.nz tel:+64(9)373-7599x6730 fax:373-7556 http://www.health.auckland.ac.nz/pharmacology/staff/nholford/