I looked at a readme text posted on line (attached) that originated from
Icon some time ago:
https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=6&cad=rja&uac
t=8&ved=2ahUKEwiQ4ozXuvLfAhWCZd8KHVW2DRIQFjAFegQIARAB&url=https%3A%2F%2Fnonm
em.iconplc.com%2Fnonmem%2Fconstrained%2520longitudinal%2520spline%2Freadme.t
xt&usg=AOvVaw07-r6tKLZsz_5GMOTYBMuM readme.txt ...
https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=6&cad=rja&uac
t=8&ved=2ahUKEwiQ4ozXuvLfAhWCZd8KHVW2DRIQFjAFegQIARAB&url=https%3A%2F%2Fnonm
em.iconplc.com%2Fnonmem%2Fconstrained%2520longitudinal%2520spline%2Freadme.t
xt&usg=AOvVaw07-r6tKLZsz_5GMOTYBMuM
https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=6&cad=rja&uac
t=8&ved=2ahUKEwiQ4ozXuvLfAhWCZd8KHVW2DRIQFjAFegQIARAB&url=https%3A%2F%2Fnonm
em.iconplc.com%2Fnonmem%2Fconstrained%2520longitudinal%2520spline%2Freadme.t
xt&usg=AOvVaw07-r6tKLZsz_5GMOTYBMuM
https://nonmem.iconplc.com/nonmem/constrained%20longitudinal%20spline/readme
.txt
1.
https://webcache.googleusercontent.com/search?q=cache:xWJ5Iy0lqgsJ: https://
nonmem.iconplc.com/nonmem/constrained%2520longitudinal%2520spline/readme.txt
+&cd=6&hl=en&ct=clnk&gl=us Cached
Nov 18, 1997 - The longitudinal splines are constrained to exhibit (i)
decreasing tail (ii) ... random effects denoted ETAj in NONMEM, where ETAj
is distributed ...
You've visited this page 5 times. Last visit: 1/15/19
When I tried to run the code for a single dose I got an error message. The
control and data (1 subject) are attached. The error message was that the
characters in error were:
Pack
$268 SUBROUTINES EEROR WHILE OPENING OR COPYING USED SUPPLIED SUBROUTINE
Control
$PROBLEM Fits the single-dose PK data with the CLS method
$DATA ..\SDSPLINE_DAT.CSV IGNORE=I
$INPUT ID TIME DV AMT MDV
$SUB OTHER=PACK OTHER=single ; on SUN/UNIX
$SUB OTHER=PACK.f OTHER=single.f ; on PC
$PRED
"FIRST
" double precision ggg(10),col(4),desp(20)
" character fname(4)*12
NB2=3
ORDER=4
NDESP=5
FRAC=.05
STEP=.1
TMAX=36
" DESP(1)=.5
" DESP(2)=2.26
" DESP(3)=3.58
" DESP(4)=5.91
" DESP(5)=10
" COL(1)=1
" COL(2)=2
" COL(3)=3
" COL(4)=5
" FNAME(1)='pred.rep'
" FNAME(2)='ipred.rep'
" FNAME(3)='mipk.rep'
" FNAME(4)='para.rep'
" call single(icall,newind,theta,datrec,frac,nb2,order,time,
" x eta,col,desp,ndesp,step,tmax,fname,cls,ggg,id,0,icro)
" do j=1,nb2-1
" g(j,1)=ggg(j)
" enddo
Y=CLS*(1+EPS(1))+EPS(2) ; any error model
; Enter nonzero values of H(i,j+1), j=1,nb2-1, when the INTERACTION
; option is used in $EST.
;
;" do j=1,nb2-1
;" h(1,j+1)=ggg(j)
;" enddo
JUNK=ETA(1)+EPS(1) ; NMTRAN requirement
$OMEGA .0625 .0625 ; diagonal
; dimension = NB2-1 due to the end-point constraint
$SIGMA .0625 .09
$EST MAX=9999 POSTHOC
$THETA
(0 FIXED) ; THETA(1) = 0 due to the end-point constraint
(0 2 INF) ; THETA(2)
(0 2 INF) ; THETA(3)
(0 2 INF) ; THETA(4)
(0 2 INF) ; THETA(5)
(0 2 INF) ; THETA(6)
;$SIMULATION(2792293 NEW) ONLYSIM SUBPROBLEMS=100
;$ESTIMATION MAX=5000,PRINT=5
;$COVARIANCE
$TABLE TIME ID Y DV
ONEHEADER NOPRINT FILE=MODEL1.fit
ID
TIME
DV
AMT
MDV
1
0
.
50
1
1
0.5
6.82
.
0
1
2.26
8.66
.
0
1
3.58
7.25
.
0
1
5.91
4.32
.
0
1
10
5.95
.
0
Splines
There is a readme text posted on line (link below) that originated from Icon
some time ago:
https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=6&cad=rja&uac
t=8&ved=2ahUKEwiQ4ozXuvLfAhWCZd8KHVW2DRIQFjAFegQIARAB&url=https%3A%2F%2Fnonm
em.iconplc.com%2Fnonmem%2Fconstrained%2520longitudinal%2520spline%2Freadme.t
xt&usg=AOvVaw07-r6tKLZsz_5GMOTYBMuM readme.txt ...
https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=6&cad=rja&uac
t=8&ved=2ahUKEwiQ4ozXuvLfAhWCZd8KHVW2DRIQFjAFegQIARAB&url=https%3A%2F%2Fnonm
em.iconplc.com%2Fnonmem%2Fconstrained%2520longitudinal%2520spline%2Freadme.t
xt&usg=AOvVaw07-r6tKLZsz_5GMOTYBMuM
https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=6&cad=rja&uac
t=8&ved=2ahUKEwiQ4ozXuvLfAhWCZd8KHVW2DRIQFjAFegQIARAB&url=https%3A%2F%2Fnonm
em.iconplc.com%2Fnonmem%2Fconstrained%2520longitudinal%2520spline%2Freadme.t
xt&usg=AOvVaw07-r6tKLZsz_5GMOTYBMuM
https://nonmem.iconplc.com/nonmem/constrained%20longitudinal%20spline/readme
.txt
1.
https://webcache.googleusercontent.com/search?q=cache:xWJ5Iy0lqgsJ: https://
nonmem.iconplc.com/nonmem/constrained%2520longitudinal%2520spline/readme.txt
+&cd=6&hl=en&ct=clnk&gl=us Cached
Nov 18, 1997 - The longitudinal splines are constrained to exhibit (i)
decreasing tail (ii) ... random effects denoted ETAj in NONMEM, where ETAj
is distributed ...
You've visited this page 5 times. Last visit: 1/15/19
When I tried to run the code for a single dose I got an error message and
since the code referenced Icon, I thought that I would ask you before
sending it to NMusers.
The control and data are attached. The error message was that the
characters in error were:
Pack
$268 SUBROUTINES EEROR WHILE OPENING OR COPYING USED SUPPLIED SUBROUTINE
SDSPLINE_DAT.csv
Description:
MS-Excel spreadsheet
TEST.ctl
Description:
Binary data
Regarding Andre Jackson's query about using the Spline example in the NONMEM
repository, the reason for the error message is that the appropriate OTHER
routines, such as pack.f and single.f, that are referenced in the control
stream file, need to be available. When using an example, it is good idea to
copy all of the pertinent files from that directory.
But this leads to another matter, that these OTHER files that some examples use
are coded in Fortran 77. These would need to be re-coded into F90 files in
order to be used in NONMEM 7. I will soon be putting out another message to
nmusers about a utility that will do that.
Robert J. Bauer, Ph.D.
Senior Director
Pharmacometrics R&D
ICON Early Phase
820 W. Diamond Avenue
Suite 100
Gaithersburg, MD 20878
Office: (215) 616-6428
Mobile: (925) 286-0769
[email protected]<mailto:[email protected]>
http://www.iconplc.com/